Journal of Photosciences

The p-Hydroxyphenacyl Photoremovable Protecting Group

Volume 10(2003), 37-48 page

ÀúÀÚ: Richard S. Givens and Jong-Ill Lee

   10-1-37.pdf (264.2K)

Keywords: p-hydroxyphenacyl  phototriggers  caged compounds  photoremovable protecting groups  neurotransmitters  nucleotides, enzyme switches, GABA  glutamate  ATP  Protein Kinase


A review of the background and development of the p-hydroxyphenacyl group (pHP) as a photoprotecting group for biological substrates is chronicled. The pHP group has promise as an efficient, rapid phototrigger for the study of very fast biological processes. Applications include the release of neurotransmittors and second messengers, enzyme switches and nucleotides.